Xgeva and Prolia (denosumab)

Xgeva and Prolia are the same drug given at different doses depending on the situation.

Xgeva is used for adult patients who have prostate cancer in their bones that’s resistant to other testosterone-lowering medical and surgical treatments. This is known as castration-resistant prostate cancer. This treatment contains denosumab, a protein (monoclonal antibody) that slows the destruction caused by bone metastasis. Xgeva prevents such serious complications as fracture or pressure on the spinal cord, and it does it without the need for radiation therapy or surgery.

Xgeva is administered once every four weeks, as a single injection under the skin. It is a safe therapy; it does not affect the kidneys, liver, or heart. However, it may lowering calcium levels in the blood, and there’s a very low risk of damage to the jaw. Patients who have extensive dental work while on this drug may develop a serious condition called osteonecrosis of the jaw (ONJ), which causes an abscess that never completely heals. We ask all patients to get a full dental checkup and schedule any dental surgeries before starting Xgeva.


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